Seed Oils, Chronic Inflammation, Heart Health & Marijuana | Ganesh Halade

Mind & Matter

Seed Oils, Chronic Inflammation, Heart Health & Marijuana | Ganesh Halade | 266

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Seed Oils, Chronic Inflammation, Heart Health & Marijuana | Ganesh Halade | 266

How dietary polyunsaturated fats, especially omega-6 from seed oils, influence inflammation & heart health.

Nick Jikomes

Dec 07, 2025

∙ Paid

Wide release date: December 7, 2025.

Topics Discussed:

Polyunsaturated fatty acids (PUFAs): Omega-6 from seed oils like safflower and corn can convert to pro-inflammatory molecules, while omega-3s produce resolving ones; imbalance biases toward chronic inflammation.
Inflammation regulation: Acute inflammation aids healing but requires active “on” and “off” signals from lipid mediators; chronic inflammation arises from excess omega-6, delaying resolution.
Heart health & diet: High omega-6 diets worsen post-heart attack outcomes in mice by elevating pro-inflammatory lipids.
Evolution & historical context: PUFAs are essential but naturally balanced in pre-industrial diets; modern processing skews ratios, contributing to diseases, as shown in early rat experiments needing minimal fats for survival.
Aging & lifestyle factors: Excess omega-6 exacerbates inflammation in older mice; sleep, exercise, and balanced fats are crucial for metabolic health and enzyme function in processing lipids.
Cannabis & omega-6 interaction: In mice on high omega-6 diets, CBD-rich cannabis smoke reaches the heart quickly, suppresses immune response, and weakens cardiac strain, unlike in balanced-diet controls.
Genetic models: FAT-1 mice converting omega-6 to omega-3 show better healing and neuroprotection; FAT-2 mice doing the opposite exhibit liver fibrosis and metabolic issues, highlighting omega-6 excess harms.

Practical Takeaways:

Balance omega-6 and omega-3 intake by reducing seed oils in processed foods and increasing sources like fish or algae to support inflammation resolution and heart health.
Monitor and adjust fat intake with age, as older individuals are more sensitive to omega-6 excess leading to immune dysregulation.
Avoid combining high omega-6 diets with smoking, as it may impair immune and cardiac responses based on animal data.

About the guest: Ganesh Halade, PhD is a cardiovascular scientist and associate professor at the University of South Florida Morsani College of Medicine.

Reference Paper: