How Does Ketamine Work in the Brain & is it Addictive?

Ketamine's unusual mechanism of action make it reinforcing & psychoactive, but with a low addiction liability.

Ketamine is a hell of a drug. It’s been used for decades as an anesthetic and has recently seen renewed scientific interest for its ability to induce rapid (though temporary) antidepressant effects. It is also used recreationally for its dissociative psychoactivity.

The type of effect you get depends on the dose. Low, sub-psychoactive doses can yield ant…